The Institute of Cell Biology performs cutting-edge research in molecular and cell biology to study a wide variety of topics that include Host Pathogen Interactions, Systems Biology, Epigenetics, Organelle Biogenesis and Developmental processes.
November 18, 2024
11:15 − 12:15
ICB Room C161, Baltzerstrasse 4, 3012 Bern
Prof. Dr. Jörn Dengjel | Department of Biology | Universty of Fribourg
Invited by Prof. Dr. Volker Heussler
November 20, 2024
12:30 − 13:30
Institute of Cell BIology l Baltzerstrasse 4 I room C161, first floor l 3012 Bern
Presenting This Week: Clirim Jetishi, Sophia Fochler
November 25, 2024
Prof. Dr. Ala Trusina | Niels Bohr Institute | University of Copenhagen
Invited by Prof. Dr. Olivier Pertz
PLoS Biology
A new study co-led by our Ambizione fellow Gaëlle Lentini characterized rhoptry discharge factor 3 as an essential factor for invasion and microtubule-associated vesicle biogenesis in Toxoplasma gondii. This study was recently published in PLoS Biology. In Toxoplasma gondii, the intracellular parasite that causes toxoplasmosis, rhoptries are essential organelles for invading host cells. This latest publication focuses on RDF3, a protein vital for the parasite's invasion process. RDF3 is required for the proper formation of microtubule-associated vesicles (MVs), which supply the rhoptries during repeated invasion cycles. Depletion of RDF3 disrupts these processes, highlighting its critical role in parasite virulence. Understanding the function of RDF3 could inform strategies to treat T. gondii and related parasite infections. Figure Legend: FIB–SEM-based 3D reconstruction of a parasitophorous vacuoel containing 16 Toxoplasma gondii tachyzoites. Grey, nucleus; green, apicoplast; blue, parasite plasma membrane; black, conoid; yellow and red, rhoptries. ©Bohumil MACO/UNIGE
Baltzerstrasse 4 3012 Bern
